Mpanda District is one of the five districts of the Katavi Region of Tanzania. Its administrative seat is the city of Mpanda. The district is bordered to the northwest by the Kigoma Region, to the northeast by the Tabora Region, to the east by the Mbeya Region, to the southeast by the Sumbawanga Urban District, to the southwest by the Nkasi District and to the west by Lake Tanganyika.